Sunderland's new signing Steven Fletcher could make his debut in the club's first home game of the new season, but fellow newcomer Adam Johnson will miss out.
Fletcher's reported £12m move from Wolves went through in time for him to be able to play some part in the game but Johnson's transfer from Manchster City was not finalised before the deadline for him to feature.
Sunderland are seeking first league win in 10 games against Reading.
Both sides are still seeking their first win of the Premier League campaign ahead of Saturday's clash at the Stadium of Light.
Brian McDermott's promoted Royals took a point from their opening encounter with Stoke, which ended in a 1-1 draw, but endured a 4-2 defeat to Chelsea at Stamford Bridge in midweek despite their hard-working display.
Sunderland, meanwhile, produced a solid defensive performance to frustrate Arsenal in a goalless draw last weekend but will be looking for three points against the Premier League newcomers on Wearside.
Martin O'Neill's side are without a win in nine top-flight games, having drawn six and lost three - a run they will be keen to address against Reading.
They will be boosted by the signing of Steven Fletcher from Wolves, with the striker available to feature against the Royals.
Sunderland can also take comfort from the fact the only teams to win at the Stadium of Light since O'Neill arrived are Arsenal and Manchester United, while Reading have won just one of their last five trips to Wearside.
The Royals will be looking to repeat their impressive form on the road from last season, when the Championship winners ended the campaign with the second best away record, winning 13 matches on their travels.
- Martin O'Neill saw his side pick up 22 points from his first 10 games in charge, but they have pocketed just 13 in their last 15 Premier League outings.
- Sunderland have failed to score in six of their last eight Premier League matches.
- Only West Ham (45) earned more points away from home than Reading (42) in the 2011-12 Championship.
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